Hubungan Kadar Alpha Fetoprotein (AFP) dengan Ukuran Tumor Hati Jenis Karsinoma Hepatoseluler di RSUD Abdul Wahab SJahranie Samarinda
DOI:
https://doi.org/10.47859/jmu.v11i01.528Keywords:
AFP Level, Hepatocellular Carcinoma, Nodule SizeAbstract
Background: Hepatocellular carcinoma results from abnormal cell formation or malignant cell changes. Hepatocellular carcinoma can be diagnosed by measuring AFP levels in serum and performing examinations through radiology, FNAB, and histopathology. Pupose: The purpose of this study was to determine the relationship between AFP levels and liver tumor size of nodular-type hepatocellular carcinoma. Method: The sample of this study amounted to 55 samples of hepatocellular carcinoma patient data for the period 2020-2022 using a purposive sampling technique. This type of research is descriptive-analytic with a retrospective approach. Results: Data analysis was performed using the Chi-Square test. The results obtained data on the characteristics of the sex of hepatocellular carcinoma patients, namely men as many as 35 patients (63.6%) and women as many as 20 patients (36.4%), age characteristics at the most incidence of hepatocellular carcinoma occurred at the age of 50-59 years (30, 9%), with AFP levels in hepatocellular carcinoma patients with normal categories as many as 33 cases (60%) and increased categories as many as 22 cases (40%), and nodule sizes < 2 cm as many as 3 cases (5.5%), 2-5 cm as many as 9 cases (16.4%), and > 5 cm as many as 43 cases (78.2%). The data was then subjected to bivariate analysis, and the results of statistical calculation p value 0.017 (<0.05) which indicates a significant relationship between AFP levels and hepatocellular carcinoma nodule size. Conclusion: the higher the AFP level, the larger the nodule size.
References
Abbasi, Amanullah., et al. (2012). Corelation Of Serum Alpha Fetoprotein And Tumor Size In Hepatocellular Carcinoma. Journal of the Pakistan Medical Association. 62(1): 33-36.
Ashwin, A. et al. (2006). Epidemiology of Primary and Secondary Liver Cancers. Journal Seminar in Interventional Radiology. 23(1): 47-63. https://doi.org/10.1055/s-2006-939841
Azzahra, Shahnaz., et al. (2023). Profile of Patients of Hepatocellular Carcinoma in The Internal Medicine Inpatient Room at Dr. Soetomo General Academic Hospital. Current Internal Medicine Research And Practice Surabaya Journal. 4(1): 1-5. https://doi.org/10.20473/cimrj.v4i1.42287
Bethesda. (2002). PDQ Cancer Information Summaries. National Cancer Intitute: US. Diakses melalui https://www.ncbi.nlm.nih.gov/books/NBK65851/
Betty., Mei Ika MC. (2018). Cirrosis Hepatis With Moderately Differentiation Hepatocellular Carsinoma, Trabecular Pattern. Jurnal Tropical Medicine. 1(2): 367-373. E-ISSN 2623-0550. https://doi.org/10.32734/tm.v1i2.218
Chao-Wei Lee., et al. (2019). Normal Alpha-Fetoprotein Hepatocelluler Carcinoma: Are They Really Normal?. Journal of Clinical Medicine. 8(10): 1736. https://doi.org/10.3390/jcm8101736.
Chaudary, P., et al. (2015). Primary Hepatic Angisarcoma. Europian Journal of Surgical Oncology, The Journal of Cancer Surgery. 41(9): 1137-1143. DOI: https://doi.org/10.1016/j.ejso.2015.04.022.
Dalimartha, S. (2004). Deteksi Dini Kanker dan Simplisia Antikanker. Jakarta: Penebar Swadaya.
Dou-Sheng Bai., et al. (2017). The Prognostic Correlation of AFP Level at Diagnosis With Pathological Grade, Progression, and Survival of Patients With Hepatocellular Carcinoma. Scientific Reports Journal. 7: 1-9. https://doi.org/10.1038/s41598-017-12834-1
Ettorre, MG. (2022). Hepatocelluler Carcinoma. Catania: Springer. https://doi.org/10.1007/978-3-031-09371-5
Force, Madison., dkk. (2022). Alpha-Fetoprotein (AFP) and AFP-L3 is Most Useful in Detection of Recurrence of Hepatocellular Carcinoma in Patients After Tumor Ablition and With Low AFP Level. MDPI Virus Journal. 14(4): 775. https://doi.org/10.3390/v14040775
Ginting, DS., et al. (2022). Anatomi Fisiologi Tubuh Manusia. Padang: Global Eksekutif Teknologi.
GLOBOCAN. (2020). Liver Cancer Fact Sheets. International Agency for Research in Cancer. Diakses melalui https://gco.iarc.fr/today/data/factsheets/cancers/11-Liver-fact-sheet.pdf
Guang-Wen Cao., Yuan-Li Wang., Zhong-Yu Guo. (2018). Staging of Hepatocelluler Carcinoma. Hepatoma Research Journal. 4: 58. https://doi.org/10.20517/2394-5079.2018.40
Huang SC., et al. (2021). Direct comparison of biopsy techniques for hepatic malignancies. Clinical and Molecular Hepatology. 27(2): 305-312. https://doi.org/10.3350/cmh.2020.0301
Julius, B., et al. (2016). Hepatocelluler Carcinoma: A Review. Journal of Hepatocelluler Carcinoma. 3: 41-53. DOI: 10.2147/JHC.S61146. Diakses melalui https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063561/
M. Mohammadian, N. Mahdavifar, A. Mohammadian-Hafshejani, and H. Salehiniya. (2018). Liver Cancer In The World: Epidemiology, Incidence, Mortality And Risk Factors. World Cancer Research Journal. 5(2): e1082. Diakses melalui Liver cancer in the world - Epidemiology, incidence, mortality and risk factors (wcrj.net)
Magdy, HA., & Shahira, A. (2015). Guide for Diagnosis and Treatment of Hepatocelluler Carcinoma. World Journal of Hepatology. 7(12): 1632-1652. https://doi.org/10.4254/wjh.v7.i12.1632
Nursriyanti, Dahvia., et al. (2023). Analysis of Alfa-Fetoprotein as A Staging Determiner of Hepatocellular Carcinoma Progresivity. Clinical Pathology and Medical Laboratory. 29(3): 268-271. E-ISSN 2477-4685. https://doi.org/10.24293/ijcpml.v29i3.2044
Oluwaseun, OA., et al. (2023). Alpha Fetoprotein. Florida: StatPearls Publisher. Diakses melalui https://www.ncbi.nlm.nih.gov/books/NBK430750/
Omata M., et al. (2010). Asian Pacific Association for the Study of the Liver Consensus Recommendations on Hepatocelluler Carcinoma. Hepatology International. 4(2): 439-474. https://doi.org/10.1007%2Fs12072-010-9165-7
Puri, DA., Murti, S., Riastiti, Y. (2021). Insidensi dan Karakteristik Karsinoma Hepatoseluler di RSUD Abdul Wahab Sjahranie Samarinda. Jurnal Sains dan Kesehatan. 3(2): 158-164. E-ISSN 2407-6082. https://doi.org/10.25026/jsk.v3i2.275
Ran Xu Zhu., et al. (2016). Epidemiology of Hepatocelluler Carcinoma in the Asia-Pacific Region. Gut and Liver Journal. 10(3): 332-339. https://doi.org/10.5009/gnl15257
Rusie, Daniel., et al. (2022). Correlation Between Serum Alpha-Fetoprotein and Tumour Size in Patients With Hepatocellular Carcinoma Treated With Direct-Acting Antivirals. Cureus Journal. 14(4): e24506. https://doi.org/10.7759/cureus.24506
Sebastião N, et al. (2019). The strengths and weaknesses of gross and histopathological evaluation in hepatocellular carcinoma: a brief review. Surgical and Experimental Pathology. 2(23): 1-12. https://doi.org/10.1186/s42047-019-0047-6
Verma, Nishu., Vinocha, Anjali. (2023). Role od CA 19.9 and CEA in Predicting Diagnosis in Hepatocelluler Carcinoma. Journal of Cancer Research and Therapeutics. 19(5): 1356-1358. https://doi.org/10.4103/jcrt.jcrt_1280_21
Vivek, Chavda., et al. (2023). Ethnic Differences In Hepatocellular Carcinoma Prevalence and Therapeutic Outcomes. Cancer Reports. 6(1): e1821. https://doi.org/10.1002/cnr2.1821
Wang, ZG., et al. (2021). Incidence and survival outcomes of secondary liver cancer: a Surveillance Epidemiology and End Results database analysis. 10(3): 1273-1283. https://doi.org/10.21037/tcr-20-3319
Wee, Aileen. (2011). Fine-Needle Aspiration Biopsy of Hepatocellular Carcinoma and Related Hepatocellular Nodular Lesions in Cirrhosis: Controversies, Challenges, and Expectations. Vol. 2011. Patholog Res Int.: Singapore. https://doi.org/10.4061/2011/587936
Wen-jun Ma., Hai-yong Wang., & Li-song Teng. (2013). Correlation Analysis of Preoperative Serum Alpha-Fetoprotein (AFP) Level and Prognosis of Hepatocelluler Carcinoma (HCC) After Hepatectomy. World Journal of Surgical Oncology. 11(212): 1-7. https://doi.org/10.1186/1477-7819-11-212
Yang HI., et al. (2002). Hepatitis B e Antigen and The Risk of Hepatocellular Carcinoma. N Engl Journal Med. 347(3): 168-174. https://doi.org/10.1056/NEJMoa013215
