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		Penurunan Fungsi Ginjal Pada Pasien Prolanis Dengan Diabetes: Sebuah Tinjauan Klinis
							| Jurnal Kesehatan Medika Udayana
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<meta name="citation_reference" content="Akinci, B., Celtik, A., Yener, S., Yesil, S. (2008). Is fasting glucose level during oral glucose tolerance test an indicator of the insulin need in gestational diabetes? Diabetes Research and Clinical Practice, 82(2):219-225."/>
<meta name="citation_reference" content="Bostom, A.G., Kronenberg, F., Ritz, E. (2002). Predictive Performance of Renal Function Equations for Patients with Chronic Kidney Disease and Normal Serum Creatinine Levels. Journal of the American Society of Nephrology, 13(8)."/>
<meta name="citation_reference" content="Cao, Z., Cooper, M.E. (2011). Pathogenesis of diabetic nephropathy. Journal of Diabetes Investigation, 2(4):243-247."/>
<meta name="citation_reference" content="Chehregosha, H., Khamseh, M.E., Malek, M., Hosseinpanah, F., Ismail-Beigi, F. (2019). A View Beyond HbA1c : Role of Continuous Glucose Monitoring. Diabetes Therapy, 10(3):853-863."/>
<meta name="citation_reference" content="Fioretto, P., Bruseghin, M., Berto, I., Gallina, P., Manzato, E., Mussap, M.. (2006). Renal Protection in Diabetes: Role of Glycemic Control. Journal of the American Society of Nephrology, 17(4_suppl_2)."/>
<meta name="citation_reference" content="Glasgow, R.E. (1995). A Practical Model of Diabetes Management and Education. Diabetes Care, 18(1):117-126."/>
<meta name="citation_reference" content="Gong, Q-H., Kang, J-F., Ying, Y-Y., Li, H., Zhang, X-H., Wu, Y-H., Xu, G-Z. (2015). Lifestyle Interventions for Adults with Impaired Glucose Tolerance: A Systematic Review and Meta-Analysis of the Effects on Glycemic Control. Internal Medicine, 54(3):303-310."/>
<meta name="citation_reference" content="Handayani, W., Muthoharoh, A., Kusuma, N. I., Tina, N. S., &amp; Nabiilah, A. (2025). Edukasi Swamedikasi kepada Masyarakat tentang Gejala Penyakit Degeneratif di Klinik PKU Muhammadiyah Comal, Pemalang. Jurnal Abdi Masyarakat Indonesia, 5(1), 43-48."/>
<meta name="citation_reference" content="Kashani, K., Rosner, M.H., Ostermann, M. (2020). Creatinine : From physiology to clinical application. European Journal of Internal Medicine, 72:9-14."/>
<meta name="citation_reference" content="MacIsaac, R.J., Ekinci, E.I., Jerums, G. (2014). ‘Progressive diabetic nephropathy. How useful is microalbuminuria?: contra’. Kidney International, 86(1):50-57."/>
<meta name="citation_reference" content="Mugiyanto. E., Cahyanta, A.N., Putra, I., Setyahadi, S., Simanjuntak, P. (2019). Identifying active compounds of soursop ethanolic fraction as ?-glucosidase inhibitor. Pharmaciana, 9(2):191-200."/>
<meta name="citation_reference" content="Ortiz, A., Covic, A., Fliser, D., Fouque, D., Goldsmith, D., Kanbay, M., Mallamaci, F., Massy, Z.A., Rossignol, P., Vanholder, R., et al (2014). Epidemiology, contributors to, and clinical trials of mortality risk in chronic kidney failure. The Lancet, 383(9931):1831-1843."/>
<meta name="citation_reference" content="Phillips, A.O., Baboolal, K., Riley, S., Gröne, H., Janssen, U., Steadman, R., Williams, J., Floege, J. (2001). Association of Prolonged Hyperglycemia With Glomerular Hypertrophy and Renal Basement Membrane Thickening in the Goto Kakizaki Model of Non–Insulin-Dependent Diabetes Mellitus. American Journal of Kidney Diseases, 37(2):400-410."/>
<meta name="citation_reference" content="Rachmawati, S., Prihhastuti-Puspitasari, H., Zairina, E.(2019). The implementation of a chronic disease management program (Prolanis) in Indonesia: a literature review, 30(6)."/>
<meta name="citation_reference" content="Rivandi, J., Yonata, A. (2015). Hubungan diabetes melitus dengan kejadian gagal ginjal kronik. Jurnal Majority, 4(9):27-34."/>
<meta name="citation_reference" content="Salazar, J.H. (2014) Overview of Urea and Creatinine. Laboratory Medicine 2014, 45(1):e19-e20."/>
<meta name="citation_reference" content="Schena, F.P., Gesualdo, L. (2005). Pathogenetic Mechanisms of Diabetic Nephropathy. Journal of the American Society of Nephrology, 16(3_suppl_1)."/>
<meta name="citation_reference" content="Schrier, R.W. (2008). Blood Urea Nitrogen and Serum Creatinine. Circulation: Heart Failure, 1(1):2-5"/>
<meta name="citation_reference" content="Slocum, J.L., Heung, M., Pennathur, S. (2012). Marking renal injury: can we move beyond serum creatinine? Translational Research, 159(4):277-289."/>
<meta name="citation_reference" content="Sumadewi, K.T., Dewi, P., Kerans, F.F.A. ( Edukasi Hipertensi dan Pelatihan Meditasi untuk Penderita Hipertensi pada Kelompok Prolanis. Warmadewa Minesterium Medical Journal 2023, 2(3):132-139"/>
<meta name="citation_reference" content="Tsalamandris, C., Allen, T.J., Gilbert, R.E., Sinha, A., Panagiotopoulos, S., Cooper, M.E., Jerums, G. (1994). Progressive Decline in Renal Function in Diabetic Patients With and Without Albuminuria. Diabetes, 43(5):649-655."/>
<meta name="citation_reference" content="Tziomalos, K., Athyros, V.G. (2015). Diabetic Nephropathy: New Risk Factors and Improvements in Diagnosis. Rev Diabet Study, 12(1-2):110-118."/>
<meta name="citation_reference" content="Xie, Y., Bowe, B., Li, T., Xian, H., Yan, Y., Al-Aly, Z. (2018). Higher blood urea nitrogen is associated with increased risk of incident diabetes mellitus. Kidney International, 93(3):741-752."/>
<meta name="citation_reference" content="Ziasti, O., Syafariyanti, A.N., Permatasari, A.T., Ariani, C.A., Wijaya, G.Y.A., Afira, N.A., Wulandari, P.D., Pangesti, R.D.D., Thiovinsky, M., Masmudah, M. (2024). Case Report: Analysis of Drug Related Problems (DRPs) in Patients with Hypertension, Diabetes Mellitus, and Hyperuricemia with Nephrolithiasis. Journal Pharmasci (Journal of Pharmacy and Science), 1-9Hidayati, S.N. (2016). Pengaruh Pendekatan Keras dan Lunak Pemimpin Organisasi terhadap Kepuasan Kerja dan Potensi Mogok Kerja Karyawan. Jurnal Maksipreneur: Manajemen, Koperasi, dan Entrepreneurship, 5(2), 57-66. http://dx.doi.org/10.30588/SOSHUMDIK.v5i2. 164."/>
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<meta name="DC.Creator.PersonalName" content="Nurul  Aktifah"/>
<meta name="DC.Creator.PersonalName" content="Nuniek Nizmah  Fajriyah"/>
<meta name="DC.Creator.PersonalName" content="Nur Intan Kusuma"/>
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<meta name="DC.Description" xml:lang="en" content="Background: Decreased kidney function is one of the serious complications of diabetes mellitus, which can develop into chronic kidney disease (CKD). This study aims to reduce kidney function in diabetic patients who are members of the Chronic Disease Management Program (Prolanis) at the Comal Pratama Clinic. Objective: The Prolanis program aims to effectively manage chronic conditions such as diabetes, these results show that most patients continue to experience significant decline in kidney function. Methods: This study involved a longitudinal analysis of Prolanis patient data, focusing on changes in creatinine and urea levels as indicators of kidney function. Clinical data used in this study included creatinine and urea levels, taken from patient medical records in 2023 and 2024. Results: The results showed a significant increase in creatinine and urea levels among the patients studied, indicating worsening kidney function during the study period. This study emphasizes the importance of closer monitoring and more specific interventions to protect kidney function in diabetic patients who are members of Prolanis. Conclusion: Most patients continue to experience significant decline in kidney function."/>
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			<article class="obj_article_details">

			<h1 class="page_title">
		Penurunan Fungsi Ginjal Pada Pasien Prolanis Dengan Diabetes: Sebuah Tinjauan Klinis
	</h1>
	
	<div class="row">
		<div class="main_entry">

							<section class="item authors">
					<h2 class="pkp_screen_reader">Authors</h2>
					<ul class="authors">
											<li>
							<span class="name">
								Widyastuti Handayani
							</span>
															<span class="affiliation">
									Universitas Muhammadiyah Pekajangan Pekalongan
																	</span>
																				</li>
											<li>
							<span class="name">
								Eko Mugiyanto
							</span>
															<span class="affiliation">
									Universitas Muhammadiyah Pekajangan Pekalongan, Indonesia
																	</span>
																				</li>
											<li>
							<span class="name">
								Ainun  Muthoharoh
							</span>
															<span class="affiliation">
									Universitas Muhammadiyah Pekajangan Pekalongan, Indonesia
																	</span>
																				</li>
											<li>
							<span class="name">
								Nurul  Aktifah
							</span>
															<span class="affiliation">
									Universitas Muhammadiyah Pekajangan, Pekalongan, Indonesia
																	</span>
																				</li>
											<li>
							<span class="name">
								Nuniek Nizmah  Fajriyah
							</span>
															<span class="affiliation">
									Universitas Muhammadiyah Pekajangan Pekalongan, Indonesia
																	</span>
																				</li>
											<li>
							<span class="name">
								Nur Intan Kusuma
							</span>
															<span class="affiliation">
									Universitas Muhammadiyah Pekajangan Pekalongan, Indonesia
																	</span>
																				</li>
											<li>
							<span class="name">
								Shavira Novita  Islamy
							</span>
															<span class="affiliation">
									Universitas Muhammadiyah Pekajangan Pekalongan, Indonesia
																	</span>
																				</li>
											<li>
							<span class="name">
								Rahma Dian  Nisa
							</span>
															<span class="affiliation">
									Universitas Muhammadiyah Pekajangan Pekalongan, Indonesia
																	</span>
																				</li>
										</ul>
				</section>
			
																												<section class="item doi">
						<h2 class="label">
														DOI:
						</h2>
						<span class="value">
							<a href="https://doi.org/10.47859/jmu.v11i02.629">
								https://doi.org/10.47859/jmu.v11i02.629
							</a>
						</span>
					</section>
							
									<section class="item keywords">
				<h2 class="label">
										Keywords:
				</h2>
				<span class="value">
											Diabetes Mellitus, 											Kidney Function, 											Creatinine, 											Urea, 											Prolanis Program									</span>
			</section>
			
										<section class="item abstract">
					<h2 class="label">Abstract</h2>
					<p><strong>Background:</strong> Decreased kidney function is one of the serious complications of diabetes mellitus, which can develop into chronic kidney disease (CKD). This study aims to reduce kidney function in diabetic patients who are members of the Chronic Disease Management Program (Prolanis) at the Comal Pratama Clinic. <strong>Objective:</strong> The Prolanis program aims to effectively manage chronic conditions such as diabetes, these results show that most patients continue to experience significant decline in kidney function. <strong>Methods:</strong> This study involved a longitudinal analysis of Prolanis patient data, focusing on changes in creatinine and urea levels as indicators of kidney function. Clinical data used in this study included creatinine and urea levels, taken from patient medical records in 2023 and 2024. <strong>Results</strong>: The results showed a significant increase in creatinine and urea levels among the patients studied, indicating worsening kidney function during the study period. This study emphasizes the importance of closer monitoring and more specific interventions to protect kidney function in diabetic patients who are members of Prolanis. <strong>Conclusion:</strong> Most patients continue to experience significant decline in kidney function.</p>
				</section>
			
			

																																																																				
										<section class="item references">
					<h2 class="label">
						References
					</h2>
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																					<p>Abdel-Hassan, I.A., Abdel-Barry JA, Tariq Mohammeda S. (2000). The hypoglycaemic and antihyperglycaemic effect of citrullus colocynthis fruit aqueous extract in normal and alloxan diabetic rabbits. J Ethnopharmacol, 71(1-2):325-330. </p>
															<p>Akinci, B., Celtik, A., Yener, S., Yesil, S. (2008). Is fasting glucose level during oral glucose tolerance test an indicator of the insulin need in gestational diabetes? Diabetes Research and Clinical Practice, 82(2):219-225. </p>
															<p>Bostom, A.G., Kronenberg, F., Ritz, E. (2002). Predictive Performance of Renal Function Equations for Patients with Chronic Kidney Disease and Normal Serum Creatinine Levels. Journal of the American Society of Nephrology, 13(8). </p>
															<p>Cao, Z., Cooper, M.E. (2011). Pathogenesis of diabetic nephropathy. Journal of Diabetes Investigation, 2(4):243-247. </p>
															<p>Chehregosha, H., Khamseh, M.E., Malek, M., Hosseinpanah, F., Ismail-Beigi, F. (2019). A View Beyond HbA1c : Role of Continuous Glucose Monitoring. Diabetes Therapy, 10(3):853-863. </p>
															<p>Fioretto, P., Bruseghin, M., Berto, I., Gallina, P., Manzato, E., Mussap, M.. (2006). Renal Protection in Diabetes: Role of Glycemic Control. Journal of the American Society of Nephrology, 17(4_suppl_2). </p>
															<p>Glasgow, R.E. (1995). A Practical Model of Diabetes Management and Education. Diabetes Care, 18(1):117-126. </p>
															<p>Gong, Q-H., Kang, J-F., Ying, Y-Y., Li, H., Zhang, X-H., Wu, Y-H., Xu, G-Z. (2015). Lifestyle Interventions for Adults with Impaired Glucose Tolerance: A Systematic Review and Meta-Analysis of the Effects on Glycemic Control. Internal Medicine, 54(3):303-310. </p>
															<p>Handayani, W., Muthoharoh, A., Kusuma, N. I., Tina, N. S., &amp; Nabiilah, A. (2025). Edukasi Swamedikasi kepada Masyarakat tentang Gejala Penyakit Degeneratif di Klinik PKU Muhammadiyah Comal, Pemalang. Jurnal Abdi Masyarakat Indonesia, 5(1), 43-48. </p>
															<p>Kashani, K., Rosner, M.H., Ostermann, M. (2020). Creatinine : From physiology to clinical application. European Journal of Internal Medicine, 72:9-14. </p>
															<p>MacIsaac, R.J., Ekinci, E.I., Jerums, G. (2014). ‘Progressive diabetic nephropathy. How useful is microalbuminuria?: contra’. Kidney International, 86(1):50-57. </p>
															<p>Mugiyanto. E., Cahyanta, A.N., Putra, I., Setyahadi, S., Simanjuntak, P. (2019). Identifying active compounds of soursop ethanolic fraction as ?-glucosidase inhibitor. Pharmaciana, 9(2):191-200. </p>
															<p>Ortiz, A., Covic, A., Fliser, D., Fouque, D., Goldsmith, D., Kanbay, M., Mallamaci, F., Massy, Z.A., Rossignol, P., Vanholder, R., et al (2014). Epidemiology, contributors to, and clinical trials of mortality risk in chronic kidney failure. The Lancet, 383(9931):1831-1843. </p>
															<p>Phillips, A.O., Baboolal, K., Riley, S., Gröne, H., Janssen, U., Steadman, R., Williams, J., Floege, J. (2001). Association of Prolonged Hyperglycemia With Glomerular Hypertrophy and Renal Basement Membrane Thickening in the Goto Kakizaki Model of Non–Insulin-Dependent Diabetes Mellitus. American Journal of Kidney Diseases, 37(2):400-410. </p>
															<p>Rachmawati, S., Prihhastuti-Puspitasari, H., Zairina, E.(2019). The implementation of a chronic disease management program (Prolanis) in Indonesia: a literature review, 30(6). </p>
															<p>Rivandi, J., Yonata, A. (2015). Hubungan diabetes melitus dengan kejadian gagal ginjal kronik. Jurnal Majority, 4(9):27-34. </p>
															<p>Salazar, J.H. (2014) Overview of Urea and Creatinine. Laboratory Medicine 2014, 45(1):e19-e20. </p>
															<p>Schena, F.P., Gesualdo, L. (2005). Pathogenetic Mechanisms of Diabetic Nephropathy. Journal of the American Society of Nephrology, 16(3_suppl_1). </p>
															<p>Schrier, R.W. (2008). Blood Urea Nitrogen and Serum Creatinine. Circulation: Heart Failure, 1(1):2-5 </p>
															<p>Slocum, J.L., Heung, M., Pennathur, S. (2012). Marking renal injury: can we move beyond serum creatinine? Translational Research, 159(4):277-289. </p>
															<p>Sumadewi, K.T., Dewi, P., Kerans, F.F.A. ( Edukasi Hipertensi dan Pelatihan Meditasi untuk Penderita Hipertensi pada Kelompok Prolanis. Warmadewa Minesterium Medical Journal 2023, 2(3):132-139 </p>
															<p>Tsalamandris, C., Allen, T.J., Gilbert, R.E., Sinha, A., Panagiotopoulos, S., Cooper, M.E., Jerums, G. (1994). Progressive Decline in Renal Function in Diabetic Patients With and Without Albuminuria. Diabetes, 43(5):649-655. </p>
															<p>Tziomalos, K., Athyros, V.G. (2015). Diabetic Nephropathy: New Risk Factors and Improvements in Diagnosis. Rev Diabet Study, 12(1-2):110-118. </p>
															<p>Xie, Y., Bowe, B., Li, T., Xian, H., Yan, Y., Al-Aly, Z. (2018). Higher blood urea nitrogen is associated with increased risk of incident diabetes mellitus. Kidney International, 93(3):741-752. </p>
															<p>Ziasti, O., Syafariyanti, A.N., Permatasari, A.T., Ariani, C.A., Wijaya, G.Y.A., Afira, N.A., Wulandari, P.D., Pangesti, R.D.D., Thiovinsky, M., Masmudah, M. (2024). Case Report: Analysis of Drug Related Problems (DRPs) in Patients with Hypertension, Diabetes Mellitus, and Hyperuricemia with Nephrolithiasis. Journal Pharmasci (Journal of Pharmacy and Science), 1-9Hidayati, S.N. (2016). Pengaruh Pendekatan Keras dan Lunak Pemimpin Organisasi terhadap Kepuasan Kerja dan Potensi Mogok Kerja Karyawan. Jurnal Maksipreneur: Manajemen, Koperasi, dan Entrepreneurship, 5(2), 57-66. <a href="http://dx.doi.org/10.30588/SOSHUMDIK.v5i2">http://dx.doi.org/10.30588/SOSHUMDIK.v5i2</a>. 164. </p>
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